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Diseases of oesophagus, stomach and duodenum

DOID EFO MESH SNOMED PheWeb

K11_OESSTODUO

gastric mucosal hypertrophy: MC)nC)trier disease (MD) is a rare premalignant hyperproliferative gastropathy characterized by massive overgrowth of foveolar cells in the gastric lining, resulting in large gastric folds, and manifesting with epigastric pain, nausea, vomiting, peripheral edema and, less commonly, anorexia and weight loss.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K20, K20#, K20-K31
Cause of death: ICD-10 K20, K20#, K20-K31

2 out of 7 registries used, show all original rules.

55468

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Check minimum number of events None

55468

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Include endpoints

59004

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Remove individuals based on genotype QC

56890

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K11_OESSTODUO

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 56890 30813 26077
Unadjusted prevalence (%) 15.09 14.62 15.68
Mean age at first event (years) 55.45 53.57 57.67

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.34 [2.11, 2.59] 3.1e-61 8209
15 years 0.01 1.43 [1.31, 1.56] 4.5e-15 3404
5 years 0.00 2.78 [2.57, 3.00] <1e-100 2207
1 year 0.00 8.23 [7.42, 9.12] <1e-100 1285

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_OESSTODUO – Diseases of oesophagus, stomach and duodenum
GWS hits: 2

Survival analyses between endpoints

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Plot

before Diseases of oesophagus, stomach and duodenum
after Diseases of oesophagus, stomach and duodenum

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diseases of oesophagus, stomach and duodenum

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Endpoint not on priority list, no data to show.