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Barrett oesophagus

DOID EFO MESH SNOMED PheWeb

K11_BARRET

Barrett's esophagus: Esophageal lesion lined with columnar metaplastic epithelium which is flat or villiform. Barrett epithelium is characterized by two different types of cells: goblet cells and columnar cells. The symptomatology of Barrett esophagus is that of gastro-esophageal reflux. It is the precursor of most esophageal adenocarcinomas. (WHO)

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K22.7
Hospital discharge: ICD-9 5301B
Cause of death: ICD-10 K22.7
Cause of death: ICD-9 5301B

2 out of 7 registries used, show all original rules.

1144

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Check minimum number of events None

1144

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Include endpoints None

1144

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Remove individuals based on genotype QC

1123

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K11_BARRET

Control definitions

Control exclude K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K22

Summary Statistics

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Key figures

All Female Male
Number of individuals 1123 383 740
Unadjusted prevalence (%) 0.30 0.18 0.45
Mean age at first event (years) 64.98 65.04 64.95

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.54 [2.61, 7.89] 9.0e-8 78
15 years 0.01 1.39 [0.74, 2.59] 3.0e-1 21
5 years 0.00 4.17 [2.29, 7.62] 3.3e-6 35
1 year 0.00 9.76 [5.01, 18.98] 2.0e-11 18

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_BARRET – Barrett oesophagus
GWS hits:

Survival analyses between endpoints

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Plot

before Barrett oesophagus
after Barrett oesophagus

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Barrett oesophagus

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Endpoint not on priority list, no data to show.