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Gastro-oesophageal reflux disease

DOID EFO MESH SNOMED PheWeb

K11_REFLUX

gastroesophageal reflux disease: A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K21
Hospital discharge: ICD-9 5301A
Cause of death: ICD-10 K21
Cause of death: ICD-9 5301A

2 out of 7 registries used, show all original rules.

27129

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Check minimum number of events None

27129

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Include endpoints None

27129

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Remove individuals based on genotype QC

26184

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K11_REFLUX

Control definitions

Control exclude K11_OESSTODUO

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K20-K31
Name in latin Morbus refluxualis gastro-oesophageus

Summary Statistics

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Key figures

All Female Male
Number of individuals 26184 15290 10894
Unadjusted prevalence (%) 6.94 7.25 6.55
Mean age at first event (years) 54.85 53.74 56.42

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.74 [1.45, 2.10] 4.5e-9 2139
15 years 0.01 1.18 [1.01, 1.37] 3.7e-2 995
5 years 0.00 2.22 [1.94, 2.53] 9.0e-32 565
1 year 0.00 4.83 [4.06, 5.75] 6.9e-71 233

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_REFLUX – Gastro-oesophageal reflux disease
GWS hits:

Survival analyses between endpoints

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Plot

before Gastro-oesophageal reflux disease
after Gastro-oesophageal reflux disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Gastro-oesophageal reflux disease

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Endpoint not on priority list, no data to show.