Disorders of the thyroid gland

E4_THYROID

thyroid nodule: A small circumscribed mass in the THYROID GLAND that can be of neoplastic growth or non-neoplastic abnormality. It lacks a well-defined capsule or glandular architecture. Thyroid nodules are often benign but can be malignant. The growth of nodules can lead to a multinodular goiter (GOITER, NODULAR).

Endpoint definition

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FinnGen phenotype data

392423 individuals

Apply sex-specific rule None

392423

Check conditions None

392423

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E00-E07

Cause of death: ICD-10 E00-E07

2 out of 7 registries used, show all original rules.

29227

Check minimum number of events None

29227

Include endpoints

E4_CONGEIOD

E4_IODGOITRE

E4_IODTHYR

E4_IODHYPSUB

E4_HYTHYSUBS

E4_HYTHYPOSTINF

E4_ATROTHY

E4_MYXOCO

E4_HYTHYNAS

E4_GOITREDIFF

E4_GOITRENOD

E4_GOITREMULTINOD

E4_GOITRENAS

E4_THYTOXGOITDIF

E4_THYTOXECT

E4_THYCRISIS

E4_THYTOXNAS

E4_THYROIDITACU

E4_THYROIDITSUBAC

E4_THYROIDITCHRON

E4_THYROIDITAUTOIM

E4_THYROIDITDRUG

E4_THYROIDITNAS

E4_HYPERSECCAL

E4_GOITREDYS

E4_THYROIDNASOTH

58514

Remove individuals based on genotype QC

56574

E4_THYROID

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

NAME	E4_THYROID
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	E4_CONGEIOD\|E4_IODGOITRE\|E4_IODTHYR\|E4_IODHYPSUB\|E4_HYTHYSUBS\|E4_HYTHYPOSTINF\|E4_ATROTHY\|E4_MYXOCO\|E4_HYTHYNAS\|E4_GOITREDIFF\|E4_GOITRENOD\|E4_GOITREMULTINOD\|E4_GOITRENAS\|E4_THYTOXGOITDIF\|E4_THYTOXECT\|E4_THYCRISIS\|E4_THYTOXNAS\|E4_THYROIDITACU\|E4_THYROIDITSUBAC\|E4_THYROIDITCHRON\|E4_THYROIDITAUTOIM\|E4_THYROIDITDRUG\|E4_THYROIDITNAS\|E4_HYPERSECCAL\|E4_GOITREDYS\|E4_THYROIDNASOTH
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E0
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E0
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Disorders of the thyroid gland based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	56574	44780	11794
Unadjusted prevalence (%)	15.00	21.24	7.09
Mean age at first event (years)	51.20	49.43	57.88

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.46 [1.29, 1.64]	9.8e-10	4306
15 years	0.01	1.07 [0.97, 1.18]	2.0e-1	2035
5 years	0.00	1.89 [1.72, 2.08]	8.1e-38	1037
1 year	0.00	2.23 [1.90, 2.63]	2.3e-22	223

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_THYROID – Disorders of the thyroid gland
GWS hits: 114

Survival analyses between endpoints

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Plot

before Disorders of the thyroid gland
after Disorders of the thyroid gland

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Disorders of the thyroid gland

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Endpoint not on priority list, no data to show.

≡ Risteys

R9

R8

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R6

R5

R4

R3