Thyrotoxicosis with diffuse goitre


Graves disease: Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland ( hyperthyroidism ).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy , antithyroid drugs, and/or thyroid surgery.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E05.0
Hospital discharge: ICD-9 2420
Hospital discharge: ICD-8 2420
Cause of death: ICD-10 E05.0
Cause of death: ICD-9 2420
Cause of death: ICD-8 2420

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E05
Name in latin Thyreotoxicosis cum struma diffusa

Summary Statistics

Key figures

All Female Male
Number of individuals 4462 3726 736
Unadjusted prevalence (%) 1.18 1.77 0.44
Mean age at first event (years) 48.86 48.00 53.18


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.42 [0.92, 2.19] 1.1e-1 191
15 years 0.01 0.92 [0.58, 1.44] 7.1e-1 86
5 years 0.00 1.58 [1.00, 2.48] 4.8e-2 42
1 year 0.00 4.65 [2.75, 7.88] 1.1e-8 22

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_THYTOXGOITDIF – Thyrotoxicosis with diffuse goitre
GWS hits: 22

Survival analyses between endpoints


before Thyrotoxicosis with diffuse goitre
after Thyrotoxicosis with diffuse goitre

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Drugs most likely to be purchased after Thyrotoxicosis with diffuse goitre

Endpoint not on priority list, no data to show.