Congenital iodine-deficiency syndrome/hypothyroidism

DOID EFO MESH SNOMED PheWeb

E4_CONGEIOD

thyroid disease: A disease involving the thyroid gland.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E00, E03.0, E03.1

Hospital discharge: ICD-9 243

Hospital discharge: ICD-8 243

Cause of death: ICD-10 E00, E03.0, E03.1

Cause of death: ICD-9 243

Cause of death: ICD-8 243

2 out of 7 registries used, show all original rules.

908

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Check minimum number of events None

908

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Include endpoints None

908

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Remove individuals based on genotype QC

877

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E4_CONGEIOD

Control definitions

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

NAME	E4_CONGEIOD
CONTROL_EXCLUDE	E4_THYROID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E00\|E03[0-1]
HD_ICD_9	243
HD_ICD_8	243
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E00\|E03[0-1]
COD_ICD_9	243
COD_ICD_8	243
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Congenital iodine-deficiency syndrome/hypothyroidism based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	877	696	181
Unadjusted prevalence (%)	0.23	0.33	0.11
Mean age at first event (years)	56.19	54.78	61.59

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.09	6.73 [3.55, 12.79]	5.6e-9	126
15 years	0.01	2.15 [1.08, 4.29]	2.9e-2	39
5 years	0.00	4.19 [1.73, 10.14]	1.5e-3	50
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_CONGEIOD – Congenital iodine-deficiency syndrome/hypothyroidism
GWS hits: 2

Survival analyses between endpoints

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Plot

before Congenital iodine-deficiency syndrome/hypothyroidism
after Congenital iodine-deficiency syndrome/hypothyroidism

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Table

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Drugs most likely to be purchased after Congenital iodine-deficiency syndrome/hypothyroidism

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Endpoint not on priority list, no data to show.