Congenital iodine-deficiency syndrome/hypothyroidism


thyroid disease: A disease involving the thyroid gland.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E00, E03.0, E03.1
Hospital discharge: ICD-9 243
Hospital discharge: ICD-8 243
Cause of death: ICD-10 E00, E03.0, E03.1
Cause of death: ICD-9 243
Cause of death: ICD-8 243

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 877 696 181
Unadjusted prevalence (%) 0.23 0.33 0.11
Mean age at first event (years) 56.19 54.78 61.59


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 6.73 [3.55, 12.79] 5.6e-9 126
15 years 0.01 2.15 [1.08, 4.29] 2.9e-2 39
5 years 0.00 4.19 [1.73, 10.14] 1.5e-3 50
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_CONGEIOD – Congenital iodine-deficiency syndrome/hypothyroidism
GWS hits: 2

Survival analyses between endpoints


before Congenital iodine-deficiency syndrome/hypothyroidism
after Congenital iodine-deficiency syndrome/hypothyroidism

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Drugs most likely to be purchased after Congenital iodine-deficiency syndrome/hypothyroidism

Endpoint not on priority list, no data to show.