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Other and/or unspecified nontoxic goitre

DOID EFO MESH SNOMED PheWeb

E4_GOITRENAS

goiter: Enlargement of the thyroid gland usually caused by lack of iodine in the diet, hyperthyroidism, or thyroid nodules. Symptoms include difficulty in breathing and swallowing.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E04.8, E04.9
Hospital discharge: ICD-9 2419
Cause of death: ICD-10 E04.8, E04.9
Cause of death: ICD-9 2419

2 out of 7 registries used, show all original rules.

2417

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Check minimum number of events None

2417

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Include endpoints None

2417

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Remove individuals based on genotype QC

2334

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E4_GOITRENAS

Control definitions

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 2334 1958 376
Unadjusted prevalence (%) 0.62 0.93 0.23
Mean age at first event (years) 54.52 53.33 60.72

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.63 [0.80, 3.32] 1.8e-1 172
15 years 0.01 1.09 [0.63, 1.89] 7.6e-1 66
5 years 0.00 2.63 [1.68, 4.11] 2.4e-5 44
1 year 0.00 5.94 [3.42, 10.31] 2.4e-10 19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_GOITRENAS – Other and/or unspecified nontoxic goitre
GWS hits: 13

Survival analyses between endpoints

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Plot

before Other and/or unspecified nontoxic goitre
after Other and/or unspecified nontoxic goitre

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Other and/or unspecified nontoxic goitre

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Endpoint not on priority list, no data to show.