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Nontoxic single thyroid nodule

DOID EFO MESH SNOMED PheWeb

E4_GOITRENOD

nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E04.1
Hospital discharge: ICD-9 2410|2462
Cause of death: ICD-10 E04.1
Cause of death: ICD-9 2410|2462

2 out of 7 registries used, show all original rules.

2107

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Check minimum number of events None

2107

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Include endpoints None

2107

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Remove individuals based on genotype QC

2027

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E4_GOITRENOD

Control definitions

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E04
Name in latin Struma atoxica uninodularis

Summary Statistics

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Key figures

All Female Male
Number of individuals 2027 1638 389
Unadjusted prevalence (%) 0.54 0.78 0.23
Mean age at first event (years) 50.98 49.34 57.88

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.57 [0.27, 1.21] 1.4e-1 97
15 years 0.00 0.41 [0.18, 0.90] 2.7e-2 38
5 years 0.00 1.14 [0.54, 2.42] 7.4e-1 23
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_GOITRENOD – Nontoxic single thyroid nodule
GWS hits: 1

Survival analyses between endpoints

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Plot

before Nontoxic single thyroid nodule
after Nontoxic single thyroid nodule

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Nontoxic single thyroid nodule

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Endpoint not on priority list, no data to show.