Nontoxic multinodular goitre


nodular goiter: Goiter characterized by discrete tissue mass(es) that may or may not produce thyroid hormones.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E04.2
Hospital discharge: ICD-9 2411
Hospital discharge: ICD-8 241
Cause of death: ICD-10 E04.2
Cause of death: ICD-9 2411
Cause of death: ICD-8 241

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Control exclude E4_THYROID

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E04
Name in latin Struma atoxica multinodularis

Summary Statistics

Key figures

All Female Male
Number of individuals 6149 5192 957
Unadjusted prevalence (%) 1.63 2.46 0.58
Mean age at first event (years) 52.50 51.39 58.48


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.92 [0.63, 1.34] 6.7e-1 495
15 years 0.00 0.68 [0.47, 0.99] 4.2e-2 224
5 years 0.00 1.12 [0.79, 1.58] 5.2e-1 91
1 year 0.00 1.47 [0.88, 2.43] 1.4e-1 21

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_GOITREMULTINOD – Nontoxic multinodular goitre
GWS hits: 47

Survival analyses between endpoints


before Nontoxic multinodular goitre
after Nontoxic multinodular goitre

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Drugs most likely to be purchased after Nontoxic multinodular goitre

Endpoint not on priority list, no data to show.