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Wet age-related macular degeneration

DOID EFO MESH SNOMED PheWeb

WET_AMD

age-related macular degeneration: Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions

not WET_AMD_EARLY

392342

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Check pre-conditions, main-only, mode, registry filters

Pre-conditions EVENT_AGE>=50
Hospital Discharge: ICD-10 H35.31
Hospital discharge: ICD-9 3625B
Cause of death: ICD-10 H35.31
Cause of death: ICD-9 3625B

2 out of 7 registries used, show all original rules.

5006

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Check minimum number of events None

5006

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Include endpoints None

5006

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Remove individuals based on genotype QC

4848

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WET_AMD

Control definitions

Control pre-conditions DEATH_AGE>=50
Control conditions not WET_AMD_EARLY

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35
Name in latin Degeneratio maculae senilis exsudativa

Summary Statistics

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Key figures

All Female Male
Number of individuals 4848 2469 2379
Unadjusted prevalence (%) 1.29 1.17 1.43
Mean age at first event (years) 75.67 75.89 75.45

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.89 [2.43, 3.43] 7.2e-33 913
15 years 0.01 1.33 [1.11, 1.61] 2.4e-3 409
5 years 0.00 2.35 [1.96, 2.81] 1.1e-20 371
1 year 0.00 3.10 [2.43, 3.95] 9.2e-20 104

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: WET_AMD – Wet age-related macular degeneration
GWS hits: 17

Survival analyses between endpoints

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Plot

before Wet age-related macular degeneration
after Wet age-related macular degeneration

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Wet age-related macular degeneration

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Endpoint not on priority list, no data to show.