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Degeneration of macula and posterior pole

DOID MESH PheWeb

H7_MACULADEGEN

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H35.30, H35.31, H35.36#, H35.37#, H35.38#, H35.39#
Hospital discharge: ICD-9 3625
Hospital discharge: ICD-8 37710
Cause of death: ICD-10 H35.30, H35.31, H35.36#, H35.37#, H35.38#, H35.39#
Cause of death: ICD-9 3625
Cause of death: ICD-8 37710

2 out of 7 registries used, show all original rules.

15624

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Check minimum number of events None

15624

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Include endpoints

15624

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Remove individuals based on genotype QC

15137

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H7_MACULADEGEN

Control definitions

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Degeneration of macula and posterior pole based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 15137 7902 7235
Unadjusted prevalence (%) 4.01 3.75 4.35
Mean age at first event (years) 71.64 71.10 72.23

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.82 [1.50, 2.21] 1.2e-9 2320
15 years 0.01 0.99 [0.84, 1.18] 9.3e-1 1056
5 years 0.00 2.12 [1.86, 2.41] 2.5e-29 895
1 year 0.00 2.96 [2.50, 3.51] 5.4e-36 253

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_MACULADEGEN – Degeneration of macula and posterior pole
GWS hits: 12

Survival analyses between endpoints

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Plot

before Degeneration of macula and posterior pole
after Degeneration of macula and posterior pole

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Drugs most likely to be purchased after Degeneration of macula and posterior pole

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Endpoint not on priority list, no data to show.