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Degenerative macular diseases

DOID EFO MESH SNOMED PheWeb

MACULA_NAS

macular degeneration: Loss of vision in the central portion of the retina (macula), secondary to retinal degeneration. [ NCIT:P378 ]

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 H35.39#
Cause of death: ICD-10 H35.39#

2 out of 7 registries used, show all original rules.

3582

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Check minimum number of events None

3582

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Include endpoints None

3582

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Remove individuals based on genotype QC

3473

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MACULA_NAS

Control definitions

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2
Parent code in ICD-10 H35
Name in latin Striae angioides maculae

Summary Statistics

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Key figures

All Female Male
Number of individuals 3473 1880 1593
Unadjusted prevalence (%) 0.92 0.89 0.96
Mean age at first event (years) 66.69 65.52 68.07

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.54 [1.01, 2.34] 4.4e-2 524
15 years 0.01 0.95 [0.63, 1.45] 8.3e-1 287
5 years 0.00 1.99 [1.44, 2.74] 2.9e-5 170
1 year 0.00 2.39 [1.57, 3.63] 4.7e-5 37

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: MACULA_NAS – Degenerative macular diseases
GWS hits: 1

Survival analyses between endpoints

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Plot

before Degenerative macular diseases
after Degenerative macular diseases

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Degenerative macular diseases

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Endpoint not on priority list, no data to show.