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Diabetic retinopathy

DOID EFO MESH SNOMED PheWeb

H7_RETINOPATHYDIAB

diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital discharge: ICD-9 3620
Cause of death: ICD-9 3620

2 out of 7 registries used, show all original rules.

7031

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Check minimum number of events None

7031

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Include endpoints

7031

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Remove individuals based on genotype QC

6818

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H7_RETINOPATHYDIAB

Control definitions

Control exclude H7_CHOROIDRETINA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 6818 3041 3777
Unadjusted prevalence (%) 1.81 1.44 2.27
Mean age at first event (years) 49.92 47.37 51.97

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.40 [3.51, 5.53] 2.2e-37 1263
15 years 0.02 2.76 [2.25, 3.39] 3.8e-22 636
5 years 0.00 4.37 [3.71, 5.15] 6.1e-69 347
1 year 0.00 5.11 [3.96, 6.59] 3.0e-36 79

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_RETINOPATHYDIAB – Diabetic retinopathy
GWS hits: 16

Survival analyses between endpoints

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Plot

before Diabetic retinopathy
after Diabetic retinopathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetic retinopathy

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Endpoint not on priority list, no data to show.