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Familial hypercholesterolemia, with ischemic heart disease

PheWeb

E4_FH_IHD

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions

I9_IHD

65782

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

2846

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Remove individuals based on genotype QC

2757

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E4_FH_IHD

Control definitions

Control conditions not I9_IHD

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF6v3

No data for upset plot.

No data for upset table.

Summary Statistics

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Key figures

All Female Male
Number of individuals 2757 900 1857
Unadjusted prevalence (%) 0.73 0.43 1.12
Mean age at first event (years) 66.23 67.48 65.63

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.21 [1.39, 3.50] 7.6e-4 661
15 years 0.01 1.36 [0.92, 2.01] 1.2e-1 324
5 years 0.00 2.79 [2.09, 3.73] 3.9e-12 205
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_FH_IHD – Familial hypercholesterolemia, with ischemic heart disease
GWS hits: 13

Survival analyses between endpoints

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Plot

before Familial hypercholesterolemia, with ischemic heart disease
after Familial hypercholesterolemia, with ischemic heart disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Familial hypercholesterolemia, with ischemic heart disease

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Endpoint not on priority list, no data to show.