Familial hypercholesterolemia

E4_FH

No definition available.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E78.00
Hospital discharge: ICD-9 2720A
Cause of death: ICD-10 E78.00
Cause of death: ICD-9 2720A

2 out of 7 registries used, show all original rules.

5112

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Check minimum number of events None

5112

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Include endpoints None

5112

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Remove individuals based on genotype QC

4965

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E4_FH

Control definitions

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF6v3

Summary Statistics

Key figures

All Female Male
Number of individuals 4965 2009 2956
Unadjusted prevalence (%) 1.32 0.95 1.78
Mean age at first event (years) 64.23 63.98 64.40

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.33 [2.54, 4.36] 1.8e-18 912
15 years 0.01 1.68 [1.28, 2.20] 1.5e-4 414
5 years 0.00 3.20 [2.55, 4.02] 1.8e-23 294
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_FH – Familial hypercholesterolemia
GWS hits: 24

Survival analyses between endpoints

Plot

before Familial hypercholesterolemia
after Familial hypercholesterolemia

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Familial hypercholesterolemia

Endpoint not on priority list, no data to show.