Familial hypercholesterolemia

E4_FH

No definition available.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E78.00

Hospital discharge: ICD-9 2720A

Cause of death: ICD-10 E78.00

Cause of death: ICD-9 2720A

2 out of 7 registries used, show all original rules.

5112

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Check minimum number of events None

5112

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Include endpoints None

5112

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Remove individuals based on genotype QC

4965

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E4_FH

Control definitions

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 5

First used in FinnGen datafreeze DF6v3

NAME	E4_FH
CONTROL_EXCLUDE	E4_METABOLIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E7800
HD_ICD_9	2720A
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E7800
COD_ICD_9	2720A
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

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Or the full data table

Similar endpoints

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List of similar endpoints to Familial hypercholesterolemia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Familial hypercholesterolemia, with ischemic heart disease

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	4965	2009	2956
Unadjusted prevalence (%)	1.32	0.95	1.78
Mean age at first event (years)	64.23	63.98	64.40

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.33 [2.54, 4.36]	1.8e-18	912
15 years	0.01	1.68 [1.28, 2.20]	1.5e-4	414
5 years	0.00	3.20 [2.55, 4.02]	1.8e-23	294
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_FH – Familial hypercholesterolemia
GWS hits: 24

Survival analyses between endpoints

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Plot

before Familial hypercholesterolemia
after Familial hypercholesterolemia

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Table

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Drugs most likely to be purchased after Familial hypercholesterolemia

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Endpoint not on priority list, no data to show.