Metabolic disorders


metabolic disease: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E70-E90
Cause of death: ICD-10 E70-E90

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Remove individuals based on genotype QC


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Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 53127 25405 27722
Unadjusted prevalence (%) 14.09 12.05 16.67
Mean age at first event (years) 62.68 61.67 63.61


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.61 [3.20, 4.08] 1.1e-95 8159
15 years 0.01 1.73 [1.55, 1.93] 5.5e-23 2925
5 years 0.00 3.91 [3.59, 4.26] <1e-100 2681
1 year 0.00 14.73 [13.34, 16.26] <1e-100 2173

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_METABOLIA – Metabolic disorders
GWS hits: 35

Survival analyses between endpoints


before Metabolic disorders
after Metabolic disorders

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Drugs most likely to be purchased after Metabolic disorders

Endpoint not on priority list, no data to show.