Pure hypercholesterolaemia


No definition available.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E78.0
Hospital discharge: ICD-9 2720
Hospital discharge: ICD-8 2720
Cause of death: ICD-10 E78.0
Cause of death: ICD-9 2720
Cause of death: ICD-8 2720

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints


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Remove individuals based on genotype QC


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Control definitions

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E78
Name in latin Hypercholesterolaemia pura

Summary Statistics

Key figures

All Female Male
Number of individuals 25928 11355 14573
Unadjusted prevalence (%) 6.88 5.39 8.76
Mean age at first event (years) 65.31 65.48 65.18


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 2.89 [2.40, 3.48] 3.3e-29 3190
15 years 0.01 1.32 [1.13, 1.54] 3.8e-4 1208
5 years 0.00 3.07 [2.71, 3.49] 2.9e-67 1158
1 year 0.00 9.28 [8.07, 10.67] <1e-100 683

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_HYPERCHOL – Pure hypercholesterolaemia
GWS hits: 41

Survival analyses between endpoints


before Pure hypercholesterolaemia
after Pure hypercholesterolaemia

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Drugs most likely to be purchased after Pure hypercholesterolaemia