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Ischaemic heart disease, wide definition

DOID EFO MESH SNOMED PheWeb

I9_IHD

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I20-I25
Hospital discharge: ICD-9 41[0-4]
Hospital discharge: ICD-8 41[0-4]
Cause of death: ICD-10 I21, I22, I23, I24, I25, I46, R96, R98
Cause of death: ICD-9 41[0-4]|798
Cause of death: ICD-8 41[0-4]|798
Cause of death: excluded ICD-9 7980A
KELA reimbursements: KELA codes 206

3 out of 7 registries used, show all original rules.

65782

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Check minimum number of events None

65782

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Include endpoints None

65782

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Remove individuals based on genotype QC

63744

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I9_IHD

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 63744 21435 42309
Unadjusted prevalence (%) 16.90 10.17 25.44
Mean age at first event (years) 63.97 64.81 63.54

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.59 [3.32, 3.89] <1e-100 19846
15 years 0.01 2.18 [2.02, 2.35] 2.1e-92 7641
5 years 0.00 3.35 [3.12, 3.60] <1e-100 3899
1 year 0.00 25.42 [22.87, 28.27] <1e-100 5314

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_IHD – Ischaemic heart disease, wide definition
GWS hits: 76

Survival analyses between endpoints

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Plot

before Ischaemic heart disease, wide definition
after Ischaemic heart disease, wide definition

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Ischaemic heart disease, wide definition

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Endpoint not on priority list, no data to show.