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Systemic connective tissue disorders

DOID EFO MESH SNOMED PheWeb

M13_SYSTCONNECT

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

12086

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Remove individuals based on genotype QC

11744

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M13_SYSTCONNECT

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Systemic connective tissue disorders based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 11744 8387 3357
Unadjusted prevalence (%) 3.11 3.98 2.02
Mean age at first event (years) 55.57 53.07 61.82

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.80 [2.28, 3.44] 8.7e-23 1350
15 years 0.01 1.36 [1.12, 1.65] 1.7e-3 521
5 years 0.00 2.94 [2.51, 3.45] 1.7e-40 433
1 year 0.00 7.31 [6.08, 8.80] 1.5e-98 227

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SYSTCONNECT – Systemic connective tissue disorders
GWS hits: 11

Survival analyses between endpoints

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Plot

before Systemic connective tissue disorders
after Systemic connective tissue disorders

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Systemic connective tissue disorders

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Endpoint not on priority list, no data to show.