Sicca syndrome [Sjögren]


Sjogren syndrome: an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain

Endpoint definition

FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None


diagram downward connector

Check conditions None


diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M35.0
Hospital discharge: ICD-9 7102
Hospital discharge: ICD-8 73490
Cause of death: ICD-10 M35.0
Cause of death: ICD-9 7102
Cause of death: ICD-8 73490

2 out of 7 registries used, show all original rules.


diagram downward connector

Check minimum number of events None


diagram downward connector

Include endpoints None


diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC


diagram downward connector

Control definitions

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M35
Name in latin Syndroma Sjögren

Summary Statistics

Key figures

All Female Male
Number of individuals 2495 2155 340
Unadjusted prevalence (%) 0.66 1.02 0.20
Mean age at first event (years) 53.26 52.59 57.55


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.72 [1.01, 2.94] 4.8e-2 182
15 years 0.01 1.18 [0.68, 2.07] 5.6e-1 86
5 years 0.00 2.11 [1.31, 3.39] 2.1e-3 43
1 year 0.00 5.58 [3.23, 9.65] 7.2e-10 21

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_SJOGREN – Sicca syndrome [Sjögren]
GWS hits: 4

Survival analyses between endpoints


before Sicca syndrome [Sjögren]
after Sicca syndrome [Sjögren]

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Sicca syndrome [Sjögren]