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Sicca syndrome [Sjögren]

DOID EFO MESH SNOMED PheWeb

M13_SJOGREN

Sjogren syndrome: an autoimmune disorder in which immune cells attack and destroy the glands that produce tears and saliva. Sjögren syndrome is also associated with rheumatic disorders such as rheumatoid arthritis or systemic lupus erythematosus. The hallmark symptoms of Sjögren syndrome are dry mouth and dry eyes. In addition, Sjogren syndrome may cause skin, nose, and vaginal dryness. It also may affect other organs of the body including the kidneys, blood vessels, lungs, liver, pancreas, and brain

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M35.0
Hospital discharge: ICD-9 7102
Hospital discharge: ICD-8 73490
Cause of death: ICD-10 M35.0
Cause of death: ICD-9 7102
Cause of death: ICD-8 73490

2 out of 7 registries used, show all original rules.

2562

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Check minimum number of events None

2562

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Include endpoints None

2562

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Remove individuals based on genotype QC

2495

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M13_SJOGREN

Control definitions

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M35
Name in latin Syndroma Sjögren

Summary Statistics

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Key figures

All Female Male
Number of individuals 2495 2155 340
Unadjusted prevalence (%) 0.66 1.02 0.20
Mean age at first event (years) 53.26 52.59 57.55

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.72 [1.01, 2.94] 4.8e-2 182
15 years 0.01 1.18 [0.68, 2.07] 5.6e-1 86
5 years 0.00 2.11 [1.31, 3.39] 2.1e-3 43
1 year 0.00 5.58 [3.23, 9.65] 7.2e-10 21

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SJOGREN – Sicca syndrome [Sjögren]
GWS hits: 4

Survival analyses between endpoints

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Plot

before Sicca syndrome [Sjögren]
after Sicca syndrome [Sjögren]

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Sicca syndrome [Sjögren]

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