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Rheumatoid arthritis

DOID EFO MESH SNOMED PheWeb

M13_RHEUMA

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M05, M06
Hospital discharge: ICD-9 7140A|7140B|7241|7142
Hospital discharge: ICD-8 712[1-3]
Cause of death: ICD-10 M05, M06
Cause of death: ICD-9 7140A|7140B|7241|7142
Cause of death: ICD-8 712[1-3]

2 out of 7 registries used, show all original rules.

12895

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Check minimum number of events None

12895

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Include endpoints None

12895

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Remove individuals based on genotype QC

12555

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M13_RHEUMA

Control definitions

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Rheumatoid arthritis based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 12555 8452 4103
Unadjusted prevalence (%) 3.33 4.01 2.47
Mean age at first event (years) 52.10 50.26 55.90

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.06 [1.71, 2.48] 3.5e-14 1573
15 years 0.01 1.49 [1.29, 1.72] 8.4e-8 751
5 years 0.00 2.17 [1.88, 2.50] 2.5e-26 341
1 year 0.00 3.35 [2.67, 4.20] 1.3e-25 99

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_RHEUMA – Rheumatoid arthritis
GWS hits: 21

Survival analyses between endpoints

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Plot

before Rheumatoid arthritis
after Rheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Rheumatoid arthritis

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