joint disease: Any disorder of the joints.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M00-M25
Cause of death: ICD-10 M00-M25

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Remove individuals based on genotype QC


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Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 136415 79942 56473
Unadjusted prevalence (%) 36.18 37.92 33.96
Mean age at first event (years) 50.16 48.77 52.12


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.23 [1.13, 1.33] 7.4e-7 12782
15 years 0.01 0.91 [0.85, 0.98] 1.1e-2 5885
5 years 0.00 1.47 [1.38, 1.57] 7.8e-30 2583
1 year 0.00 2.46 [2.21, 2.74] 1.6e-59 794

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_ARTHROPATHIES – Arthropathies
GWS hits: 31

Survival analyses between endpoints


before Arthropathies
after Arthropathies

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Drugs most likely to be purchased after Arthropathies

Endpoint not on priority list, no data to show.