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Seropositive rheumatoid arthritis, strict definition

DOID EFO MESH SNOMED PheWeb

RHEUMA_SEROPOS_STRICT

Felty's syndrome: Felty syndrome (FS), also known as ''super rheumatoid'' disease, is a severe form of rheumatoid arthritis (RA), characterized by a triad of RA, splenomegaly and neutropenia, resulting in susceptibility to bacterial infections.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions

RHEUMA_SEROPOS_OTH_ICD10

9142

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Check pre-conditions, main-only, mode, registry filters

KELA reimbursements: KELA codes ANY
KELA reimbursements: ICD-10 M05

1 out of 7 registries used, show all original rules.

4409

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Check minimum number of events None

4409

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Include endpoints None

4409

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Remove individuals based on genotype QC

4290

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RHEUMA_SEROPOS_STRICT

Control definitions

Control conditions not RHEUMA_SEROPOS_OTH_ICD10

Extra metadata

First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 4290 2962 1328
Unadjusted prevalence (%) 1.14 1.41 0.80
Mean age at first event (years) 55.26 53.46 59.27

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.39 [1.73, 3.30] 1.1e-7 364
15 years 0.01 1.71 [1.25, 2.34] 7.3e-4 204
5 years 0.00 2.30 [1.73, 3.06] 8.7e-9 86
1 year 0.00 2.52 [1.50, 4.22] 4.5e-4 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_SEROPOS_STRICT – Seropositive rheumatoid arthritis, strict definition
GWS hits: 6

Survival analyses between endpoints

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Plot

before Seropositive rheumatoid arthritis, strict definition
after Seropositive rheumatoid arthritis, strict definition

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Seropositive rheumatoid arthritis, strict definition

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Endpoint not on priority list, no data to show.