Seronegative rheumatoid arthritis

RHEUMA_SERONEG

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M06.0
Hospital discharge: ICD-9 7140B
Cause of death: ICD-10 M06.0
Cause of death: ICD-9 7140B

2 out of 7 registries used, show all original rules.

3967

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Check minimum number of events None

3967

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Include endpoints None

3967

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Remove individuals based on genotype QC

3877

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RHEUMA_SERONEG

Control definitions

Control exclude RHEUMA_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M06
Name in latin Arthritis rheumatoides seronegativa

Summary Statistics

Key figures

All Female Male
Number of individuals 3877 2732 1145
Unadjusted prevalence (%) 1.03 1.30 0.69
Mean age at first event (years) 53.58 51.86 57.69

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.00 [1.51, 2.65] 1.4e-6 366
15 years 0.01 1.32 [1.03, 1.68] 2.8e-2 179
5 years 0.00 1.75 [1.29, 2.37] 3.1e-4 78
1 year 0.00 2.65 [1.65, 4.25] 5.0e-5 22

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: RHEUMA_SERONEG – Seronegative rheumatoid arthritis
GWS hits: 4

Survival analyses between endpoints

Plot

before Seronegative rheumatoid arthritis
after Seronegative rheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Seronegative rheumatoid arthritis

Endpoint not on priority list, no data to show.