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Seronegative rheumatoid arthritis

DOID EFO MESH SNOMED PheWeb

RHEUMA_SERONEG

rheumatoid arthritis: A chronic, systemic autoimmune disorder characterized by inflammation in the synovial membranes and articular surfaces. It manifests primarily as a symmetric, erosive polyarthritis that spares the axial skeleton and is typically associated with the presence in the serum of rheumatoid factor.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M06.0
Hospital discharge: ICD-9 7140B
Cause of death: ICD-10 M06.0
Cause of death: ICD-9 7140B

2 out of 7 registries used, show all original rules.

3967

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Check minimum number of events None

3967

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Include endpoints None

3967

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Remove individuals based on genotype QC

3877

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RHEUMA_SERONEG

Control definitions

Control exclude RHEUMA_ENDPOINTS

Extra metadata

First used in FinnGen datafreeze DF3
Parent code in ICD-10 M06
Name in latin Arthritis rheumatoides seronegativa

Summary Statistics

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Key figures

All Female Male
Number of individuals 3877 2732 1145
Unadjusted prevalence (%) 1.03 1.30 0.69
Mean age at first event (years) 53.58 51.86 57.69

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.00 [1.51, 2.65] 1.4e-6 366
15 years 0.01 1.32 [1.03, 1.68] 2.8e-2 179
5 years 0.00 1.75 [1.29, 2.37] 3.1e-4 78
1 year 0.00 2.65 [1.65, 4.25] 5.0e-5 22

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: RHEUMA_SERONEG – Seronegative rheumatoid arthritis
GWS hits: 4

Survival analyses between endpoints

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Plot

before Seronegative rheumatoid arthritis
after Seronegative rheumatoid arthritis

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Seronegative rheumatoid arthritis

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Endpoint not on priority list, no data to show.