Dorsopathies

M13_DORSOPATHY

discitis: Inflammation of an intervertebral disc or disk space which may lead to disk erosion. Until recently, discitis has been defined as a nonbacterial inflammation and has been attributed to aseptic processes (e.g., chemical reaction to an injected substance). However, recent studies provide evidence that infection may be the initial cause, but perhaps not the promoter, of most cases of discitis. Discitis has been diagnosed in patients following discography, myelography, lumbar puncture, paravertebral injection, and obstetrical epidural anesthesia. Discitis following chemonucleolysis (especially with chymopapain) is attributed to chemical reaction by some and to introduction of microorganisms by others.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M40-M54
Cause of death: ICD-10 M40-M54

2 out of 7 registries used, show all original rules.

97177

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Check minimum number of events None

97177

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Remove individuals based on genotype QC

106313

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M13_DORSOPATHY

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Dorsopathies based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 106313 61634 44679
Unadjusted prevalence (%) 28.19 29.24 26.87
Mean age at first event (years) 49.86 48.62 51.56

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.38 [1.26, 1.51] 5.2e-12 9876
15 years 0.01 0.99 [0.92, 1.07] 8.4e-1 4324
5 years 0.00 1.80 [1.68, 1.94] 5.9e-56 2223
1 year 0.00 3.93 [3.53, 4.38] <1e-100 910

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_DORSOPATHY – Dorsopathies
GWS hits: 40

Survival analyses between endpoints

Plot

before Dorsopathies
after Dorsopathies

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Drugs most likely to be purchased after Dorsopathies

Endpoint not on priority list, no data to show.