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Deforming dorsopathies

DOID EFO MESH SNOMED PheWeb

M13_DEFORMDORSO

scoliosis: A congenital or acquired spinal deformity characterized by lateral curvature of the spine.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M40-M43
Cause of death: ICD-10 M40-M43

2 out of 7 registries used, show all original rules.

9123

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Check minimum number of events None

9123

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Include endpoints

9945

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Remove individuals based on genotype QC

9672

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M13_DEFORMDORSO

Control definitions

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Deforming dorsopathies based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 9672 6506 3166
Unadjusted prevalence (%) 2.56 3.09 1.90
Mean age at first event (years) 48.98 48.57 49.84

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.23 [1.63, 3.06] 6.1e-7 467
15 years 0.01 1.37 [0.99, 1.89] 6.1e-2 211
5 years 0.00 2.31 [1.68, 3.17] 2.5e-7 124
1 year 0.00 3.61 [2.42, 5.38] 2.9e-10 38

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_DEFORMDORSO – Deforming dorsopathies
GWS hits: 3

Survival analyses between endpoints

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Plot

before Deforming dorsopathies
after Deforming dorsopathies

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Deforming dorsopathies

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Endpoint not on priority list, no data to show.