causalgia: Complex regional pain syndrome type 2 (CRPS2), or causalgia is a form of complex regional pain syndrome that develops after damage to a peripheral nerve and is characterized by spontaneous pain, allodynia and hyperalgesia , not necessarily limited to the territory of the injured nerve, as well as at some point, edema, changes in skin blood flow or sudomotor dysfunction in the pain area.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Remove individuals based on genotype QC


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Control definitions

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 59438 36585 22853
Unadjusted prevalence (%) 15.76 17.35 13.74
Mean age at first event (years) 50.81 49.53 52.87


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 1.94 [1.71, 2.19] 7.9e-25 5046
15 years 0.01 1.20 [1.08, 1.32] 5.0e-4 1972
5 years 0.00 2.60 [2.38, 2.84] 2.7e-100 1355
1 year 0.00 6.69 [5.95, 7.52] <1e-100 704

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_DORSALGIA – Dorsalgia
GWS hits: 18

Survival analyses between endpoints


before Dorsalgia
after Dorsalgia

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Drugs most likely to be purchased after Dorsalgia

Endpoint not on priority list, no data to show.