Other intervertebral disc disorders

M13_INTERVERTEB

lumbar disc degeneration: Any disease of a degenerative nature that affects the intervertebral disc.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M51
Hospital discharge: ICD-9 722
Hospital discharge: ICD-8 725
Hospital discharge: excluded ICD-9 7220|7224|7227|7228A
Hospital discharge: excluded ICD-8 7250
Cause of death: ICD-10 M51
Cause of death: ICD-9 722
Cause of death: ICD-8 725
Cause of death: excluded ICD-9 7220|7224|7227|7228A
Cause of death: excluded ICD-8 7250

2 out of 7 registries used, show all original rules.

38827

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Check minimum number of events None

38827

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Include endpoints None

38827

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Remove individuals based on genotype QC

37636

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M13_INTERVERTEB

Control definitions

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M50-M54
Name in latin Aliae morbositates discorum intervertebralium

Summary Statistics

Key figures

All Female Male
Number of individuals 37636 21280 16356
Unadjusted prevalence (%) 9.98 10.09 9.84
Mean age at first event (years) 49.87 49.32 50.59

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.18 [1.03, 1.35] 1.9e-2 2748
15 years 0.01 0.94 [0.84, 1.06] 3.0e-1 1320
5 years 0.00 1.37 [1.21, 1.55] 4.0e-7 495
1 year 0.00 1.71 [1.38, 2.12] 7.6e-7 110

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: M13_INTERVERTEB – Other intervertebral disc disorders
GWS hits: 32

Survival analyses between endpoints

Plot

before Other intervertebral disc disorders
after Other intervertebral disc disorders

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Drugs most likely to be purchased after Other intervertebral disc disorders