Spondylopathies

M13_SPONDYLOPATHY

ankylosing spondylitis: An autoimmune chronic inflammatory disorder characterized by inflammation in the vertebral joints of the spine and sacroiliac joints. It predominantly affects young males. Patients present with stiffness and pain in the spine.

Endpoint definition

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FinnGen phenotype data

392423 individuals

Apply sex-specific rule None

392423

Check conditions None

392423

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M45-M49

Cause of death: ICD-10 M45-M49

2 out of 7 registries used, show all original rules.

37330

Check minimum number of events None

37330

Include endpoints

M13_ANKYLOSPON

M13_SPINENTHES

M13_SACROILIITIS

M13_OSTEOMYELVERTEB

M13_DISCINFECTION

M13_DISCITIS

M13_SPONDYLOINFECTION

M13_SPONDYLINFLAMNAS

M13_SPONDYLOSIS

M13_SPINSTENOSIS

M13_FORESTIER

M13_KISSING

M13_SPONDYLOTRAUM

M13_FATIGFRACT

M13_VERTEBCOLLAPSE

M13_SPONDYLOPATHYNAS

M13_SPONDYLOPATHINOTH

39383

Remove individuals based on genotype QC

38276

M13_SPONDYLOPATHY

Control definitions

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

NAME	M13_SPONDYLOPATHY
CONTROL_EXCLUDE	M13_DORSOPATHY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	M13_ANKYLOSPON\|M13_SPINENTHES\|M13_SACROILIITIS\|M13_OSTEOMYELVERTEB\|M13_DISCINFECTION\|M13_DISCITIS\|M13_SPONDYLOINFECTION\|M13_SPONDYLINFLAMNAS\|M13_SPONDYLOSIS\|M13_SPINSTENOSIS\|M13_FORESTIER\|M13_KISSING\|M13_SPONDYLOTRAUM\|M13_FATIGFRACT\|M13_VERTEBCOLLAPSE\|M13_SPONDYLOPATHYNAS\|M13_SPONDYLOPATHINOTH
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M4[5-9]
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M4[5-9]
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Spondylopathies based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	38276	20464	17812
Unadjusted prevalence (%)	10.15	9.71	10.71
Mean age at first event (years)	58.44	57.81	59.16

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	1.77 [1.57, 1.99]	1.6e-21	4298
15 years	0.01	1.24 [1.13, 1.36]	6.9e-6	2119
5 years	0.00	1.88 [1.72, 2.06]	2.2e-42	1056
1 year	0.00	3.46 [3.02, 3.96]	1.7e-71	368

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SPONDYLOPATHY – Spondylopathies
GWS hits: 27

Survival analyses between endpoints

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Plot

before Spondylopathies
after Spondylopathies

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Table

Loading survival analyses table

Drugs most likely to be purchased after Spondylopathies

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Endpoint not on priority list, no data to show.

≡ Risteys

R9

R8

R7

R6

R5

R4

R3