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Spondylolisthesis/Spondylolysis

DOID EFO MESH SNOMED PheWeb

M13_SPONDYLOLISTHESIS

spondylolisthesis: A condition in which there is forward displacement of a vertebral bone over the on below it.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M43.0, M43.1
Hospital discharge: ICD-9 7384
Cause of death: ICD-10 M43.0, M43.1
Cause of death: ICD-9 7384

2 out of 7 registries used, show all original rules.

5890

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Check minimum number of events None

5890

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Include endpoints None

5890

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Remove individuals based on genotype QC

5766

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M13_SPONDYLOLISTHESIS

Control definitions

Control exclude M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 5766 3745 2021
Unadjusted prevalence (%) 1.53 1.78 1.22
Mean age at first event (years) 55.76 56.02 55.28

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.32 [1.70, 3.18] 1.3e-7 258
15 years 0.01 1.44 [1.02, 2.04] 3.8e-2 127
5 years 0.00 2.23 [1.56, 3.18] 1.2e-5 68
1 year 0.00 3.05 [1.81, 5.14] 2.7e-5 19

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_SPONDYLOLISTHESIS – Spondylolisthesis/Spondylolysis
GWS hits: 4

Survival analyses between endpoints

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Plot

before Spondylolisthesis/Spondylolysis
after Spondylolisthesis/Spondylolysis

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Drugs most likely to be purchased after Spondylolisthesis/Spondylolysis

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Endpoint not on priority list, no data to show.