Heart failure,strict

DOID EFO MESH SNOMED PheWeb

I9_HEARTFAIL

systolic heart failure: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I11.0, I13.0, I13.2, I50

Hospital discharge: ICD-9 4029B|428

Hospital discharge: ICD-8 42700|42710|428|7824

Cause of death: ICD-10 I11.0, I13.0, I13.2, I50

Cause of death: ICD-9 4029B|428

Cause of death: ICD-8 42700|42710|428|7824

KELA reimbursements: KELA codes 201

Medicine purchases: ATC C03CA01|C03EB01

4 out of 7 registries used, show all original rules.

28212

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Check minimum number of events

Min. number of events 3, and need other rules

28212

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Include endpoints None

28212

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Remove individuals based on genotype QC

27304

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I9_HEARTFAIL

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF6

NAME	I9_HEARTFAIL
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	I50\|I110\|I130\|I132
HD_ICD_9	4029B\|428
HD_ICD_8	42700\|42710\|428\|7824
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	I50\|I110\|I130\|I132
COD_ICD_9	4029B\|428
COD_ICD_8	42700\|42710\|428\|7824
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB	201
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER	YES
KELA_ATC	C03CA01\|C03EB01
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Heart failure,strict based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	27304	9989	17315
Unadjusted prevalence (%)	7.24	4.74	10.41
Mean age at first event (years)	69.09	69.15	69.06

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.09	4.85 [4.40, 5.34]	<1e-100	11662
15 years	0.02	2.47 [2.25, 2.71]	1.2e-82	4718
5 years	0.01	3.96 [3.66, 4.28]	<1e-100	3656
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HEARTFAIL – Heart failure,strict
GWS hits: 5

Survival analyses between endpoints

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Plot

before Heart failure,strict
after Heart failure,strict

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Table

Loading survival analyses table

Drugs most likely to be purchased after Heart failure,strict

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