Heart failure,strict


systolic heart failure: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I11.0, I13.0, I13.2, I50
Hospital discharge: ICD-9 4029B|428
Hospital discharge: ICD-8 42700|42710|428|7824
Cause of death: ICD-10 I11.0, I13.0, I13.2, I50
Cause of death: ICD-9 4029B|428
Cause of death: ICD-8 42700|42710|428|7824
KELA reimbursements: KELA codes 201
Medicine purchases: ATC C03CA01|C03EB01

4 out of 7 registries used, show all original rules.


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Check minimum number of events

Min. number of events 3, and need other rules


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF6

Similar endpoints

List of similar endpoints to Heart failure,strict based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 27304 9989 17315
Unadjusted prevalence (%) 7.24 4.74 10.41
Mean age at first event (years) 69.09 69.15 69.06


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.09 4.85 [4.40, 5.34] <1e-100 11662
15 years 0.02 2.47 [2.25, 2.71] 1.2e-82 4718
5 years 0.01 3.96 [3.66, 4.28] <1e-100 3656
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: I9_HEARTFAIL – Heart failure,strict
GWS hits: 5

Survival analyses between endpoints


before Heart failure,strict
after Heart failure,strict

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Drugs most likely to be purchased after Heart failure,strict