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All-cause Heart Failure

DOID EFO MESH SNOMED PheWeb

I9_HEARTFAIL_ALLCAUSE

congestive heart failure: Failure of the heart to pump a sufficient amount of blood to meet the needs of the body tissues, resulting in tissue congestion and edema. Signs and symptoms include shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions

not I9_HYPERTROCARDMYOP

391341

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

27765

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Remove individuals based on genotype QC

26872

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I9_HEARTFAIL_ALLCAUSE

Control definitions

Control exclude I9_NONISCHCARDMYOP
Control conditions not I9_HYPERTROCARDMYOP

Extra metadata

First used in FinnGen datafreeze DF3

No data for upset plot.

No data for upset table.

Summary Statistics

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Key figures

All Female Male
Number of individuals 26872 9836 17036
Unadjusted prevalence (%) 7.13 4.67 10.25
Mean age at first event (years) 69.24 69.26 69.22

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.16 [0.10, 0.26] 1.3e-14 11529
15 years 0.02 2.43 [2.22, 2.67] 5.7e-81 4647
5 years 0.01 4.03 [3.74, 4.34] <1e-100 3626
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HEARTFAIL_ALLCAUSE – All-cause Heart Failure
GWS hits: 4

Survival analyses between endpoints

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Plot

before All-cause Heart Failure
after All-cause Heart Failure

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after All-cause Heart Failure

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Endpoint not on priority list, no data to show.