Cardiovascular diseases (excluding rheumatic etc)

DOID EFO MESH SNOMED PheWeb

FG_CVD

cardiovascular disease: A disease involving the cardiovascular system.

Endpoint definition

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FinnGen phenotype data

392423 individuals

Apply sex-specific rule None

392423

Check conditions None

392423

Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

Check minimum number of events None

Include endpoints

FG_HYPERTENSION

I9_ISCHHEART

I9_PULMEMB

FG_OTHHEART

FG_CEREBVASC

FG_DOAAC

FG_DISVEINLYMPH

FG_OTH

191115

Remove individuals based on genotype QC

185353

FG_CVD

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF2

NAME	FG_CVD
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	FG_HYPERTENSION\|I9_ISCHHEART\|I9_PULMEMB\|FG_OTHHEART\|FG_CEREBVASC\|FG_DOAAC\|FG_DISVEINLYMPH\|FG_OTH
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

No data for upset plot.

No data for upset table.

Similar endpoints

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List of similar endpoints to Cardiovascular diseases (excluding rheumatic etc) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	185353	88849	96504
Unadjusted prevalence (%)	49.15	42.15	58.04
Mean age at first event (years)	53.34	50.89	55.59

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	4.38 [4.12, 4.67]	<1e-100	33194
15 years	0.01	2.94 [2.73, 3.17]	<1e-100	14394
5 years	0.00	4.22 [3.88, 4.59]	<1e-100	6088
1 year	0.00	19.24 [16.49, 22.46]	<1e-100	4316

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: FG_CVD – Cardiovascular diseases (excluding rheumatic etc)
GWS hits: 74

Survival analyses between endpoints

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Plot

before Cardiovascular diseases (excluding rheumatic etc)
after Cardiovascular diseases (excluding rheumatic etc)

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Cardiovascular diseases (excluding rheumatic etc)

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Endpoint not on priority list, no data to show.

≡ Risteys

R9

R8

R7

R6

R5

R4

R3