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Hypertension

DOID EFO MESH SNOMED PheWeb

I9_HYPTENS

hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I10-I15, I67.4
Hospital discharge: ICD-9 4019X|4029A|4029B|4039A|4040A|4059A|4059B|4372A|4059X
Hospital discharge: ICD-8 400|401|402|403|404
Cause of death: ICD-10 I10-I15, I67.4
Cause of death: ICD-9 4019X|4029A|4029B|4039A|4040A|4059A|4059B|4372A|4059X
Cause of death: ICD-8 400|401|402|403|404
KELA reimbursements: KELA codes 205

3 out of 7 registries used, show all original rules.

114979

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Check minimum number of events None

114979

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Include endpoints None

114979

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Remove individuals based on genotype QC

111581

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I9_HYPTENS

Control definitions

Control exclude I9_HYPERTENSION

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 111581 52785 58796
Unadjusted prevalence (%) 29.59 25.04 35.36
Mean age at first event (years) 57.10 56.81 57.35

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.05 [1.91, 2.20] 6.6e-84 20154
15 years 0.01 1.37 [1.28, 1.46] 2.6e-19 8791
5 years 0.00 2.13 [2.00, 2.27] <1e-100 4302
1 year 0.00 6.12 [5.54, 6.76] <1e-100 2269

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HYPTENS – Hypertension
GWS hits: 253

Survival analyses between endpoints

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Plot

before Hypertension
after Hypertension

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypertension

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Endpoint not on priority list, no data to show.