Hyperfunction of pituitary gland

E4_HYPERPIT

hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E22
Cause of death: ICD-10 E22

2 out of 7 registries used, show all original rules.

1384

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Check minimum number of events None

1384

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Remove individuals based on genotype QC

1460

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E4_HYPERPIT

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Hyperfunctio hypophysis

Similar endpoints

List of similar endpoints to Hyperfunction of pituitary gland based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

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Summary Statistics

Key figures

All Female Male
Number of individuals 1460 1120 340
Unadjusted prevalence (%) 0.39 0.53 0.20
Mean age at first event (years) 38.54 35.76 47.69

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.42 [1.34, 4.38] 3.5e-3 77
15 years 0.01 1.21 [0.67, 2.18] 5.4e-1 25
5 years 0.00 2.08 [1.04, 4.15] 3.9e-2 13
1 year 0.00 14.22 [7.54, 26.83] 2.4e-16 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_HYPERPIT – Hyperfunction of pituitary gland
GWS hits:

Survival analyses between endpoints

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before Hyperfunction of pituitary gland
after Hyperfunction of pituitary gland

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Drugs most likely to be purchased after Hyperfunction of pituitary gland

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