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Hyperfunction of pituitary gland

DOID EFO MESH SNOMED PheWeb

E4_HYPERPIT

hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E22
Cause of death: ICD-10 E22

2 out of 7 registries used, show all original rules.

1384

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Check minimum number of events None

1384

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Include endpoints

1523

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Remove individuals based on genotype QC

1460

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E4_HYPERPIT

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E20-E35
Name in latin Hyperfunctio hypophysis

Similar endpoints

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List of similar endpoints to Hyperfunction of pituitary gland based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 1460 1120 340
Unadjusted prevalence (%) 0.39 0.53 0.20
Mean age at first event (years) 38.54 35.76 47.69

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.42 [1.34, 4.38] 3.5e-3 77
15 years 0.01 1.21 [0.67, 2.18] 5.4e-1 25
5 years 0.00 2.08 [1.04, 4.15] 3.9e-2 13
1 year 0.00 14.22 [7.54, 26.83] 2.4e-16 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPERPIT – Hyperfunction of pituitary gland
GWS hits:

Survival analyses between endpoints

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Plot

before Hyperfunction of pituitary gland
after Hyperfunction of pituitary gland

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Drugs most likely to be purchased after Hyperfunction of pituitary gland

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Endpoint not on priority list, no data to show.