Acromegaly and pituitary gigantism

E4_ACROMEG

hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

Endpoint definition

FinnGen phenotype data

392423 individuals

diagram downward connector

Apply sex-specific rule None

392423

diagram downward connector

Check conditions None

392423

diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E22.0
Hospital discharge: ICD-9 2530
Hospital discharge: ICD-8 2530
Hospital discharge: excluded ICD-8 25301
Cause of death: ICD-10 E22.0
Cause of death: ICD-9 2530
Cause of death: ICD-8 2530
Cause of death: excluded ICD-8 25301

2 out of 7 registries used, show all original rules.

189

diagram downward connector

Check minimum number of events None

189

diagram downward connector

Include endpoints None

189

diagram downward connector
diagram bullet diagram downward connector

Remove individuals based on genotype QC

183

diagram downward connector
E4_ACROMEG

Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E22
Name in latin Acromegalia

Summary Statistics

Key figures

All Female Male
Number of individuals 183 116 67
Unadjusted prevalence (%) 0.05 0.06 0.04
Mean age at first event (years) 45.47 44.16 47.75

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: E4_ACROMEG – Acromegaly and pituitary gigantism
GWS hits:

Survival analyses between endpoints

Plot

before Acromegaly and pituitary gigantism
after Acromegaly and pituitary gigantism

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Acromegaly and pituitary gigantism

Endpoint not on priority list, no data to show.