Acromegaly and pituitary gigantism


hyperpituitarism: Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle stimulating hormone ; and adrenocorticotropic hormone. Hyperpituitarism usually is caused by a functional adenoma.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E22.0
Hospital discharge: ICD-9 2530
Hospital discharge: ICD-8 2530
Hospital discharge: excluded ICD-8 25301
Cause of death: ICD-10 E22.0
Cause of death: ICD-9 2530
Cause of death: ICD-8 2530
Cause of death: excluded ICD-8 25301

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Include endpoints None


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Remove individuals based on genotype QC


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Control definitions

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E22
Name in latin Acromegalia

Summary Statistics

Key figures

All Female Male
Number of individuals 183 116 67
Unadjusted prevalence (%) 0.05 0.06 0.04
Mean age at first event (years) 45.47 44.16 47.75


Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: E4_ACROMEG – Acromegaly and pituitary gigantism
GWS hits:

Survival analyses between endpoints


before Acromegaly and pituitary gigantism
after Acromegaly and pituitary gigantism

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Drugs most likely to be purchased after Acromegaly and pituitary gigantism

Endpoint not on priority list, no data to show.