Diabetic neuropathy


diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None


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Check conditions None


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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E1[0-4]4
Hospital discharge: ICD-9 2505
Hospital discharge: ICD-8 25005
Cause of death: ICD-10 E1[0-4]4
Cause of death: ICD-9 2505
Cause of death: ICD-8 25005

2 out of 7 registries used, show all original rules.


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Check minimum number of events None


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Remove individuals based on genotype QC


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Control definitions

Control exclude DM_COMORB

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Diabetic neuropathy based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 2843 1003 1840
Unadjusted prevalence (%) 0.75 0.48 1.11
Mean age at first event (years) 57.16 54.03 58.86


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.34 [2.71, 6.95] 1.0e-9 754
15 years 0.02 2.55 [1.88, 3.44] 1.1e-9 331
5 years 0.00 4.05 [3.15, 5.20] 6.9e-28 219
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: DM_NEUROPATHY – Diabetic neuropathy
GWS hits: 2

Survival analyses between endpoints


before Diabetic neuropathy
after Diabetic neuropathy

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Drugs most likely to be purchased after Diabetic neuropathy

Endpoint not on priority list, no data to show.