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Diabetic neuropathy

DOID EFO MESH SNOMED PheWeb

DM_NEUROPATHY

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E1[0-4]4
Hospital discharge: ICD-9 2505
Hospital discharge: ICD-8 25005
Cause of death: ICD-10 E1[0-4]4
Cause of death: ICD-9 2505
Cause of death: ICD-8 25005

2 out of 7 registries used, show all original rules.

2932

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Check minimum number of events None

2932

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Include endpoints

2932

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Remove individuals based on genotype QC

2843

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DM_NEUROPATHY

Control definitions

Control exclude DM_COMORB

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Diabetic neuropathy based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 2843 1003 1840
Unadjusted prevalence (%) 0.75 0.48 1.11
Mean age at first event (years) 57.16 54.03 58.86

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.34 [2.71, 6.95] 1.0e-9 754
15 years 0.02 2.55 [1.88, 3.44] 1.1e-9 331
5 years 0.00 4.05 [3.15, 5.20] 6.9e-28 219
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_NEUROPATHY – Diabetic neuropathy
GWS hits: 2

Survival analyses between endpoints

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Plot

before Diabetic neuropathy
after Diabetic neuropathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetic neuropathy

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Endpoint not on priority list, no data to show.