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Type 1 diabetes with neurological complications

DOID EFO MESH SNOMED PheWeb

E4_DM1NEU

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 E10.4+, E10.4+G59.0, E10.4+G63.2, E10.4+G73.0, E10.4+G99.0
Hospital discharge: ICD-9 2505B
Cause of death: ICD-9 2505B

2 out of 7 registries used, show all original rules.

1102

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Check minimum number of events None

1102

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Include endpoints None

1102

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Remove individuals based on genotype QC

1077

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E4_DM1NEU

Control definitions

Control exclude E4_DIABETES

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF3

Summary Statistics

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Key figures

All Female Male
Number of individuals 1077 487 590
Unadjusted prevalence (%) 0.29 0.23 0.35
Mean age at first event (years) 46.87 43.98 49.26

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.49 [1.50, 8.14] 3.8e-3 186
15 years 0.02 2.42 [1.33, 4.40] 3.9e-3 84
5 years 0.01 5.16 [3.15, 8.45] 7.2e-11 52
1 year 0.00 8.87 [4.78, 16.46] 4.4e-12 17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_DM1NEU – Type 1 diabetes with neurological complications
GWS hits: 2

Survival analyses between endpoints

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Plot

before Type 1 diabetes with neurological complications
after Type 1 diabetes with neurological complications

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Drugs most likely to be purchased after Type 1 diabetes with neurological complications

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Endpoint not on priority list, no data to show.