Diabetic polyneuropathy

DM_POLYNEURO

diabetic neuropathy: A chronic, pathological complication associated with diabetes mellitus, where nerve damages are incurred due to diabetic microvascular injury involving small blood vessels that supply these nerves, resulting in peripheral and/or autonomic nerve dysfunction.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 G63.2*E10.4, G63.2*E11.4
Cause of death: ICD-10 G63.2*E10.4, G63.2*E11.4

2 out of 7 registries used, show all original rules.

1091

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Check minimum number of events None

1091

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Include endpoints None

1091

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Remove individuals based on genotype QC

1048

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DM_POLYNEURO

Control definitions

Control exclude DM_NEUROPATHY

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1048 363 685
Unadjusted prevalence (%) 0.28 0.17 0.41
Mean age at first event (years) 59.72 56.15 61.62

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.07 4.63 [2.69, 7.96] 2.9e-8 193
15 years 0.01 2.39 [1.38, 4.16] 1.9e-3 86
5 years 0.00 4.45 [2.66, 7.44] 1.2e-8 64
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: DM_POLYNEURO – Diabetic polyneuropathy
GWS hits: 2

Survival analyses between endpoints

Plot

before Diabetic polyneuropathy
after Diabetic polyneuropathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Diabetic polyneuropathy

Endpoint not on priority list, no data to show.