Pregnancy hypertension

O15_HYPTENSPREG

preeclampsia: Preeclampsia is a hypertensive disorder of pregnancy that is characterized by new-onset hypertension with proteinuria presenting after 20 weeks of gestation, and depending on mild or severe forms may initially present with severe headache, visual disturbances, and hyperreflexia.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule

Sex only females

219462

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Check conditions None

219462

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 O10, O11, O13, O14, O15, O16
Hospital discharge: ICD-9 642
Hospital discharge: ICD-8 63701|63703|63704|63709|63710|63799|66120
Cause of death: ICD-10 O10, O11, O13, O14, O15, O16
Cause of death: ICD-9 642
Cause of death: ICD-8 63701|63703|63704|63709|63710|63799

2 out of 7 registries used, show all original rules.

15128

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Check minimum number of events None

15128

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Include endpoints None

15128

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Remove individuals based on genotype QC

14727

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O15_HYPTENSPREG

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Similar endpoints

List of similar endpoints to Pregnancy hypertension based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 14727 14727 -
Unadjusted prevalence (%) 3.91 6.99 -
Mean age at first event (years) 29.65 29.65 -

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.01 0.75 [0.60, 0.95] 1.5e-2 271
15 years 0.00 0.53 [0.40, 0.70] 1.1e-5 84
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: O15_HYPTENSPREG – Pregnancy hypertension
GWS hits: 16

Survival analyses between endpoints

Plot

before Pregnancy hypertension
after Pregnancy hypertension

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Drugs most likely to be purchased after Pregnancy hypertension