Arthrosis

DOID EFO MESH SNOMED PheWeb

M13_ARTHROSIS

Hemarthrosis: Bleeding into the joints. It may arise from trauma or spontaneously in patients with hemophilia.

Endpoint definition

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FinnGen phenotype data

392423 individuals

Apply sex-specific rule None

392423

Check conditions None

392423

Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 M15-M19

Cause of death: ICD-10 M15-M19

2 out of 7 registries used, show all original rules.

73551

Check minimum number of events None

73551

Include endpoints

M13_ARTHROSIS_POLY

M13_ARTHTROSIS_COX

M13_ARTHROSIS_KNEE

M13_ARTHROSIS_OTH

75826

Remove individuals based on genotype QC

73710

M13_ARTHROSIS

Control definitions

Control exclude M13_ARTHROPATHIES

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

NAME	M13_ARTHROSIS
CONTROL_EXCLUDE	M13_ARTHROPATHIES
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	M13_ARTHROSIS_POLY\|M13_ARTHTROSIS_COX\|M13_ARTHROSIS_KNEE\|M13_ARTHROSIS_OTH
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M1[5-9]
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M1[5-9]
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Arthrosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	73710	42697	31013
Unadjusted prevalence (%)	19.55	20.25	18.65
Mean age at first event (years)	59.32	59.08	59.65

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.28 [1.16, 1.41]	1.3e-6	7455
15 years	0.01	0.96 [0.88, 1.04]	3.1e-1	3708
5 years	0.00	1.46 [1.35, 1.57]	2.4e-21	1641
1 year	0.00	1.84 [1.62, 2.10]	3.4e-20	389

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_ARTHROSIS – Arthrosis
GWS hits: 56

Survival analyses between endpoints

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Plot

before Arthrosis
after Arthrosis

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Arthrosis

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≡ Risteys

R9

R8

R7

R6

R5

R4

R3