Diseases of liver

DOID EFO MESH SNOMED PheWeb

K11_LIVER

liver disease: A disease involving the liver.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K70-K77, K77.0*B96.8

Cause of death: ICD-10 K70-K77, K77.0*B96.8

2 out of 7 registries used, show all original rules.

10230

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Check minimum number of events None

10230

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Include endpoints

K11_ALCOLIV

K11_TOXLIV

K11_HEPFAIL

K11_FIBROCHIRLIV

K11_LIVDISINOTH

11175

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Remove individuals based on genotype QC

10827

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K11_LIVER

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

NAME	K11_LIVER
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	K11_ALCOLIV\|K11_TOXLIV\|K11_HEPFAIL\|K11_CHRONHEP\|K11_FIBROCHIRLIV\|K11_OTHINFLIV\|K11_DISLIVOTH\|K11_LIVDISINOTH
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	K7
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	K7
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Diseases of liver based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	10827	5291	5536
Unadjusted prevalence (%)	2.87	2.51	3.33
Mean age at first event (years)	53.81	52.35	55.21

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.18 [3.28, 5.33]	9.5e-31	2138
15 years	0.01	1.68 [1.37, 2.07]	5.5e-7	550
5 years	0.01	4.78 [4.06, 5.63]	1.0e-78	503
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_LIVER – Diseases of liver
GWS hits: 8

Survival analyses between endpoints

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Plot

before Diseases of liver
after Diseases of liver

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Table

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Drugs most likely to be purchased after Diseases of liver

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Endpoint not on priority list, no data to show.