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Fibrosis and cirrhosis of liver

DOID EFO MESH SNOMED PheWeb

K11_FIBROCHIRLIV

cirrhosis of liver: A disorder characterized by replacement of the liver parenchyma with fibrous tissue and regenerative nodules. It is usually caused by alcoholism, hepatitis B, and hepatitis C. Complications include the development of ascites, esophageal varices, bleeding, and hepatic encephalopathy.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K74
Hospital discharge: ICD-9 571[5-6]
Hospital discharge: ICD-8 5719
Cause of death: ICD-10 K74
Cause of death: ICD-9 571[5-6]
Cause of death: ICD-8 5719

2 out of 7 registries used, show all original rules.

1900

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Check minimum number of events None

1900

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Include endpoints None

1900

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Remove individuals based on genotype QC

1841

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K11_FIBROCHIRLIV

Control definitions

Control exclude K11_LIVER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K70-K77
Name in latin Fibrosis et cirrhosis hepatis

Summary Statistics

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Key figures

All Female Male
Number of individuals 1841 966 875
Unadjusted prevalence (%) 0.49 0.46 0.53
Mean age at first event (years) 60.07 57.58 62.81

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.14 9.68 [5.66, 16.56] 1.1e-16 470
15 years 0.01 1.89 [1.04, 3.44] 3.7e-2 82
5 years 0.01 7.76 [5.04, 11.93] 1.1e-20 137
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_FIBROCHIRLIV – Fibrosis and cirrhosis of liver
GWS hits: 4

Survival analyses between endpoints

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Plot

before Fibrosis and cirrhosis of liver
after Fibrosis and cirrhosis of liver

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Fibrosis and cirrhosis of liver

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Endpoint not on priority list, no data to show.