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Nonalcoholic fatty liver disease

DOID EFO MESH SNOMED PheWeb

NAFLD

non-alcoholic fatty liver disease: A term referring to fatty replacement of the hepatic parenchyma which is not related to alcohol use.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K76.0
Cause of death: ICD-10 K76.0

2 out of 7 registries used, show all original rules.

2371

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Check minimum number of events None

2371

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Include endpoints None

2371

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Remove individuals based on genotype QC

2275

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NAFLD

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K76
Name in latin Degeneratio adiposa hepatis non alibi classificata

Summary Statistics

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Key figures

All Female Male
Number of individuals 2275 1275 1000
Unadjusted prevalence (%) 0.60 0.60 0.60
Mean age at first event (years) 53.32 54.35 52.00

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.43 [1.02, 5.80] 4.6e-2 138
15 years 0.01 1.62 [0.75, 3.49] 2.2e-1 63
5 years 0.00 3.65 [1.97, 6.76] 3.8e-5 39
1 year 0.00 13.18 [6.95, 25.00] 3.0e-15 25

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: NAFLD – Nonalcoholic fatty liver disease
GWS hits: 5

Survival analyses between endpoints

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Plot

before Nonalcoholic fatty liver disease
after Nonalcoholic fatty liver disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Nonalcoholic fatty liver disease

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