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Alcoholic liver disease

DOID EFO MESH SNOMED PheWeb

K11_ALCOLIV

Hepatitis, Alcoholic: INFLAMMATION of the LIVER due to ALCOHOL ABUSE. It is characterized by NECROSIS of HEPATOCYTES, infiltration by NEUTROPHILS, and deposit of MALLORY BODIES. Depending on its severity, the inflammatory lesion may be reversible or progress to LIVER CIRRHOSIS.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K70
Hospital discharge: ICD-9 571[0-3]
Hospital discharge: ICD-8 5710
Cause of death: ICD-10 K70
Cause of death: ICD-9 571[0-3]
Cause of death: ICD-8 5710

2 out of 7 registries used, show all original rules.

2827

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Check minimum number of events None

2827

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Include endpoints None

2827

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Remove individuals based on genotype QC

2761

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K11_ALCOLIV

Control definitions

Control exclude K11_LIVER

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K70-K77
Name in latin Morbus hepatis alcoholicus

Summary Statistics

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Key figures

All Female Male
Number of individuals 2761 671 2090
Unadjusted prevalence (%) 0.73 0.32 1.26
Mean age at first event (years) 57.22 54.84 57.99

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.12 8.61 [5.42, 13.68] 7.4e-20 1083
15 years 0.02 2.70 [1.76, 4.15] 5.7e-6 229
5 years 0.01 8.22 [6.14, 11.02] 3.3e-45 216
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_ALCOLIV – Alcoholic liver disease
GWS hits: 5

Survival analyses between endpoints

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Plot

before Alcoholic liver disease
after Alcoholic liver disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Alcoholic liver disease

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Endpoint not on priority list, no data to show.