Biliary cirrhosis, NAS

CHIRBIL_NAS

primary biliary cirrhosis: Primary biliary cholangitis (PBC) is a chronic and slowly progressive cholestatic liver disease of autoimmune etiology characterized by injury of the intrahepatic bile ducts that may eventually lead to liver failure.

Endpoint definition

FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 K74.5
Cause of death: ICD-10 K74.5

2 out of 7 registries used, show all original rules.

76

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Check minimum number of events None

76

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Include endpoints None

76

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Remove individuals based on genotype QC

74

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CHIRBIL_NAS

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K74
Name in latin Cirrhosis biliaris non specificata

Summary Statistics

Key figures

All Female Male
Number of individuals 74 48 26
Unadjusted prevalence (%) 0.02 0.02 0.02
Mean age at first event (years) 61.20 60.57 62.37

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: CHIRBIL_NAS – Biliary cirrhosis, NAS
GWS hits:

Survival analyses between endpoints

Plot

before Biliary cirrhosis, NAS
after Biliary cirrhosis, NAS

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Biliary cirrhosis, NAS

Endpoint not on priority list, no data to show.