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Valvular heart disease excluding rheumatic fever

DOID EFO MESH SNOMED PheWeb

I9_VHD

heart valve disease: A disease involving the cardial valve.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters None

0 out of 7 registries used, show all original rules.

0

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Check minimum number of events None

0

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Include endpoints

21598

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Remove individuals based on genotype QC

20929

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I9_VHD

Control definitions

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

No data for upset plot.

No data for upset table.

Similar endpoints

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List of similar endpoints to Valvular heart disease excluding rheumatic fever based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All Female Male
Number of individuals 20929 8852 12077
Unadjusted prevalence (%) 5.55 4.20 7.26
Mean age at first event (years) 66.04 65.52 66.42

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.22 [2.74, 3.77] 1.9e-46 4088
15 years 0.01 1.62 [1.43, 1.84] 4.1e-14 1581
5 years 0.00 3.15 [2.81, 3.53] 3.0e-87 1327
1 year 0.00 9.96 [8.80, 11.27] <1e-100 876

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_VHD – Valvular heart disease excluding rheumatic fever
GWS hits: 8

Survival analyses between endpoints

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Plot

before Valvular heart disease excluding rheumatic fever
after Valvular heart disease excluding rheumatic fever

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Drugs most likely to be purchased after Valvular heart disease excluding rheumatic fever

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Endpoint not on priority list, no data to show.