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Non-rheumatic valve diseases

DOID EFO MESH SNOMED PheWeb

I9_NONRHEVALV

heart valve disease: A disease involving the cardial valve.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Hospital Discharge: ICD-10 I34, I35, I36, I37
Hospital discharge: ICD-9 424
Hospital discharge: ICD-8 39[4-6]|424
Hospital discharge: excluded ICD-8 4249|3940|3950|3960|3970
Cause of death: ICD-10 I34, I35, I36, I37
Cause of death: ICD-9 424
Cause of death: ICD-8 39[4-6]|424
Cause of death: excluded ICD-8 4249|3940|3950|3960|3970

2 out of 7 registries used, show all original rules.

21435

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Check minimum number of events None

21435

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Include endpoints None

21435

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Remove individuals based on genotype QC

20772

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I9_NONRHEVALV

Control definitions

Control exclude I9_OTHHEART

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 20772 8796 11976
Unadjusted prevalence (%) 5.51 4.17 7.20
Mean age at first event (years) 66.26 65.74 66.65

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.34 [2.91, 3.85] 7.5e-64 4061
15 years 0.01 1.68 [1.47, 1.92] 1.1e-14 1568
5 years 0.00 3.34 [2.99, 3.73] 1.3e-100 1321
1 year 0.00 10.32 [9.13, 11.66] <1e-100 875

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_NONRHEVALV – Non-rheumatic valve diseases
GWS hits: 10

Survival analyses between endpoints

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Plot

before Non-rheumatic valve diseases
after Non-rheumatic valve diseases

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Non-rheumatic valve diseases

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Endpoint not on priority list, no data to show.