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Myocardial infarction, strict

DOID EFO MESH SNOMED PheWeb

I9_MI_STRICT

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

Endpoint definition

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FinnGen phenotype data

392423 individuals

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Apply sex-specific rule None

392423

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Check conditions None

392423

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Check pre-conditions, main-only, mode, registry filters

Check only main diagnosis Yes, side diagnoses are not checked
Hospital Discharge: ICD-10 I21, I22
Hospital discharge: ICD-9 410
Hospital discharge: ICD-8 410
Hospital discharge: excluded ICD-10 I21.90, I21.97, I22.90, I22.97
Cause of death: ICD-10 I21, I22
Cause of death: ICD-9 410
Cause of death: ICD-8 410
Cause of death: excluded ICD-10 I21.90, I21.97, I22.90, I22.97

2 out of 7 registries used, show all original rules.

25023

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Check minimum number of events None

25023

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Include endpoints None

25023

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Remove individuals based on genotype QC

24185

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I9_MI_STRICT

Control definitions

Control exclude I9_ISCHHEART

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF4

Summary Statistics

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Key figures

All Female Male
Number of individuals 24185 6287 17898
Unadjusted prevalence (%) 6.41 2.98 10.76
Mean age at first event (years) 66.27 69.39 65.17

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 3.90 [3.46, 4.39] <1e-100 9291
15 years 0.01 1.87 [1.69, 2.07] 3.9e-34 3089
5 years 0.00 3.24 [2.98, 3.53] <1e-100 1857
1 year 0.01 28.27 [25.60, 31.21] <1e-100 3385

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_MI_STRICT – Myocardial infarction, strict
GWS hits: 53

Survival analyses between endpoints

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Plot

before Myocardial infarction, strict
after Myocardial infarction, strict

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Myocardial infarction, strict

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