Major coronary heart disease event

DOID EFO MESH PheWeb

I9_CHD

intermediate coronary syndrome: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.

Endpoint definition

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FinnGen phenotype data

392423 individuals

Apply sex-specific rule None

392423

Check conditions None

392423

Check pre-conditions, main-only, mode, registry filters

Check only main diagnosis Yes, side diagnoses are not checked

Hospital Discharge: ICD-10 I20.0, I21, I22

Hospital discharge: ICD-9 410|4110

Hospital discharge: ICD-8 410|4110

Cause of death: ICD-10 I21, I22, I23, I24, I25, I46, R96, R98

Cause of death: ICD-9 41[0-4]|798

Cause of death: ICD-8 41[0-4]|798

Cause of death: excluded ICD-9 7980A

2 out of 7 registries used, show all original rules.

35381

Check minimum number of events None

35381

Include endpoints

I9_REVASC

I9_MI

44925

Remove individuals based on genotype QC

43518

I9_CHD

Control definitions

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF2

NAME	I9_CHD
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE	I9_REVASC\|I9_MI
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY	YES
HD_ICD_10_ATC
HD_ICD_10	I200\|I21\|I22
HD_ICD_9	410\|4110
HD_ICD_8	410\|4110
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY	YES
COD_ICD_10	I2[1-5]\|I46\|R96\|R98
COD_ICD_9	41[0-4]\|798
COD_ICD_8	41[0-4]\|798
COD_ICD_10_EXCL
COD_ICD_9_EXCL	7980A
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Show upset plot detailing case counts by codes

Or the full data table

Similar endpoints

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List of similar endpoints to Major coronary heart disease event based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	43518	12521	30997
Unadjusted prevalence (%)	11.54	5.94	18.64
Mean age at first event (years)	65.98	68.00	65.16

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.07	3.99 [3.63, 4.39]	<1e-100	15210
15 years	0.01	2.06 [1.89, 2.26]	1.9e-56	5168
5 years	0.00	3.26 [3.02, 3.53]	<1e-100	2767
1 year	0.01	33.58 [30.39, 37.09]	<1e-100	5633

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_CHD – Major coronary heart disease event
GWS hits: 73

Survival analyses between endpoints

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Plot

before Major coronary heart disease event
after Major coronary heart disease event

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Major coronary heart disease event

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≡ Risteys

R9

R8

R7

R6

R5

R4

R3